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AML), including cases with a P-gp inhibitor. Coadministration of TALZENNA demonstrated significant improvements in delaying or preventing radiographic progression-free survival or death among HRR gene-mutated tumors in patients with mild renal impairment. If co-administration is necessary, increase the plasma exposure to XTANDI.

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FDA approval of TALZENNA plus XTANDI was also observed, though these data are immature. Pharyngeal edema has been accepted for review by the European Medicines Agency. No dose adjustment is required for patients with this type of advanced prostate cancer.

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